A potential gene involved in the sexual dimorphism of cardiovascular diseases is the Ephx2 that encodes for the protein of soluble epoxide hydrolase (sEH) and is responsible for converting cardioprotective mediators, namely epoxyeicosatrienoic acids (EETs; members of epoxy fatty acid family), to their corresponding non‐ or less bioactive diols (dihydroxyeicosatrienoic acids, DHETs) (Kersten et al. Here, EPHX2 is linked to cardiovascular disorder.