HFE and metabolic dysfunction-associated steatohepatitis: 2011; Rolo et al. 2012). Insulin resistance, itself associated with oxidative stress, is commonly observed both in individuals with NASH and also in those with hemochromatosis (Smith and Adams 2011; Simcox and McClain 2013). Given the prevalence of Hfe gene mutations and shared pathogenic mechanisms with NASH, they have received intense interest in recent years as potential cofactors in NAFLD disease progression.