CAMK2G and insomnia: 2015). For instance, the increased vigilance and decreased REM sleep of insomnia may indicate that P/Q‐type channels and/or the CaMKII pathway is/are overactivated in relation to N‐type channels and the cAMP/PKA pathway. One approach would be partial blockade of P/Q‐type Ca2+ channels to reduce gamma oscillations, and therefore overarousal.