PROCR and malaria: Nevertheless, our results suggest that severe malaria can be precipitated in the absence of ICAM1 binding (e.g. by EPCR‐binding DC8 PfEMP1 previously found not to bind ICAM1; Avril et al, 2012; Claessens et al, 2012) and that ICAM1 binding in absence of EPCR binding (via group B‐C PfEMP1 not binding EPCR; Janes et al, 2011) is not an important determinant of severe malaria.