Hence, we have performed a series of studies to comprehensively evaluate antifungal properties of CD101 against both echinocandin‐susceptible and ‐resistant Candida strains, from in vitro susceptibility, enzyme activity assessment, mutant prevention assay, to in vivo PK study and efficacy evaluation against echinocandin‐susceptible and ‐resistant C. albicans strains in a mouse model of invasive candidiasis. The gene discussed is CD101; the disease is Candidiasis, Invasive.