A similar protective role of NG2 against oxidative stress has been shown in a study reporting that human glioma cells expressing high levels of NG2 were less sensitive to oxidative stress than cells with low levels of NG2.32 Given these findings, it is interesting that our in vitro studies showed increased caspase 3/7 activity after 12 h exposure to oligomer-EP amylin, when NG2 lysate levels were also decreased. This evidence concerns the gene IAPP and central nervous system cancer.