IAPP and Alzheimer disease: Since these amyloid peptides are well-established hallmarks of cerebral amyloid angiopathy (CAA) and AD pathology, it was hypothesised that amylin could potentially be involved in AD pathology,1 a hypothesis justified by the increasing number of studies showing a similarity and interaction between Aβ and amylin.1,9–11 The impact of amylin on brain function has moreover been demonstrated in a preclinical study in which rats overexpressing human amylin showed neurological deficits and neuroinflammation.12