In this study, SARI inhibited tumour angiogenesis by directly targeting Cp and inhibiting the HIF-1α/VEGF axis with important implications for colon tumour formation in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colonic tumorigenesis and colon cancer cell subcutaneous cancer models. Here, HIF1A is linked to malignant colon neoplasm.