FCGR2A and bacterial infectious disease with sepsis: Similarly, Fc function was not required for MEDI4893* protection from lethal bacteremia since MEDI4893*N297Q, containing an Fc mutation which abrogates binding to the Fc region of IgG (FcγR) and complement C3a (9, 41, 42), exhibited efficacy similar to what was observed with unmutated MEDI4893* (see Fig. S2 in the supplemental material).