TP53 and sarcoma: Based on the above, in this study, we performed in vivo (mice sarcoma S-180 tumor model) and in vitro (S-180 and human cervical carcinoma Hela cells) experiments to explore the potential mechanism of anti-tumor by using confocal microscopy, western blot, histology and immunohistochemical staining, and immunofluorescence staining etc. For the first time, we found that LNT could directly interact with tumor cells for initiating p53-dependent pathway to suppress tumor cell proliferation but showed no cytotoxicity against normal cells in vitro.