However, while the lack of CARP1 or CARP2 expression prevents the development of a DCM phenotype, biomarkers for hypertrophy such as ANF, BNP and skeletal actin continued to be elevated at the mRNA level in CMP1 and CMP2 mice (Supplementary Fig. 4a–c). The gene discussed is NPPB; the disease is familial dilated cardiomyopathy.