TNF and ulcerative colitis: The treatment of ulcerative colitis (UC) patients with moderate to severe inflammatory activity with anti-tumor necrosis factor alpha (TNFα) antibodies leads to a clinical remission rate of 10% (ULTRA1 study, 80/40 mg adalimumab) [1] to 39% (ACT1 study, infliximab 5 mg/kg body weight [2] and SUCCESS study [3]) after 8 weeks of therapy.