An evaluation of studies investigating the association of TP53 to risk of death by head and neck squamous cell carcinoma, identified that even though readily available effect sizes would confirm that TP53 is a strongly significant prognostic factor, after standardizing definitions of TP53 status and outcomes across papers and retrieving non-readily available information, this association was completely abrogated [48]. This evidence concerns the gene TP53 and head and neck squamous cell carcinoma.