INS and type 1 diabetes mellitus: For many patients with type 1 diabetes it is difficult to maintain normal blood glucose levels with the currently available therapies, which include multiple daily insulin injections or continuous subcutaneous insulin infusion with or without the use of a continuous glucose monitor.6 These therapies are all patient-managed; the patient has to make treatment decisions multiple times per day to control his blood glucose and it requires a substantial commitment from the patient in order to reach treatment goals.