In humans, SIRT3 is found downregulated in several cancers, such as ovarian, breast, liver and gastric cancers (Finley et al. 2011; Zhang and Zhou 2012; Yang et al. 2014), potentially via an increased mitochondrial oxidative stress (Schieber and Chandel 2014; Kim et al. 2010) and associated changes in cell metabolism (Haigis et al. 2012). The gene discussed is SIRT3; the disease is cancer.