aaRSs were first implicated in CMT in 2003, when four heterozygous mutations in GARS (E71G, L129P, G240R, G526R), encoding cytoplasmic GlyRS, were reported as causative for CMT type 2D (CMT2D) and distal hereditary motor neuropathy type Va (HMN5A) 23. Here, GARS1 is linked to Charcot-Marie-Tooth disease.