For the CMT‐associated aaRSs, functions beyond aminoacylation have been described for GlyRS, TyrRS, MetRS, and HisRS 70, 71, 72, 73, 74, 75, 76, 77, and CMT‐causing mutations could possibly interfere with these functions. This evidence concerns the gene YARS1 and Charcot-Marie-Tooth disease.