MAPK1 and myeloid sarcoma: Consistent with the inflammatory properties of Methanobrevibacter and Akkermansia32, 33, 34, 36, 45, 46, we found positive correlations with these organisms and gene expression in T cells and monocytes involved in key pathways previously implicated in MS pathogenesis, including increased expression of the MAPK family in monocytes (MAPK1 and MAPK14), genes directly involved in both the initiation phase of innate immunity and activating adaptive immunity50.