In T cells, Methanobrevibacter and Akkermansia positively correlated with TRAF5, a known regulator of T-cell activation and known to be overexpressed in MS, as well as STAT5B, whose expression is indispensible for the encephalitogenicity of autoreactive CD4+ T cells in EAE50, 51. The gene discussed is TRAF5; the disease is myeloid sarcoma.