The molecular mechanism underlying the effects of Li in BD still remains unknown, despite several studies shedding light on some of Li's potential mechanisms, such as its action in GSK3-signaling, in the inhibition of inositol monophosphate and its role in extracellular-regulated kinase and in GABAergic transmission via gephyrin phosphorylation.58, 59, 60 However, it is still unclear whether Li-mediated adaptations can be exclusively attributed to these mechanisms. Here, GPHN is linked to Behcet disease.