H2AX and cervical adenocarcinoma: Our initial analysis of miR146a showed that its overexpression strongly elicited DNA damage in HeLa (human cervical adenocarcinoma) and GES-1 cells (human gastric epithelial cells) upon treatment with the replication stress inducer HU and the DNA ICL-inducing agent cisplatin, as measured by γ-H2AX foci staining (Figure 1A and Supplementary Figure S1A, respectively).