EFEMP1 and neoplasm: By immunohistochemistry, the tumor xenografts formed by the high invasive subclones consisted of more EFEMP1 positive tumor tissues, compared to that formed by the EFEMP1 shRNA infected cells (S1–124,S1–125,S1–126), and the S21-exEFEMP1 infected group also has more EFEMP1 positive tumor tissues than the low invasive subclone group (Figure 7A).