We decided to focus on BRAF600E, and selected a panel of ten colorectal cancer cell lines with either WT or BRAF600E. These ten cell lines well represent other driver mutations in colon cancer such as APC, β-catenin, PIK3CA, p53, or SMAD4, but all have WT KRAS (Table S1). The gene discussed is SMAD4; the disease is malignant colon neoplasm.