DDIT3 and cancer: We further explored the publicly available drug sensitivity data in cell lines from the Genomics of Drug Sensitivity in Cancer Project (Sanger Institute, http://www.cancerrxgene.org), and found that APC or RAS mutation is an independently predictor of Temsirolimus resistance in digestive cancer cells (Figure 6D), which induces CHOP/DR5-dependent apoptosis in CRC cells similarly as Everolimus as we have shown [19].