CTSL and ovarian cancer: Interestingly, we found that CTSL silencing signicantly potentiated apoptosis induced by paclitaxel in SKOV3/TAX with CTSL knockdown compared to SKOV3/TAX transfected with control shRNA, suggesting CTSL contributes to paclitaxel resistance in ovarian cancer cells and that CTSL silencing can enhance paclitaxel mediated cell apoptosis (Figure 5A and 5B).