Interestingly, we found that CTSL silencing signicantly potentiated apoptosis induced by paclitaxel in SKOV3/TAX with CTSL knockdown compared to SKOV3/TAX transfected with control shRNA, suggesting CTSL contributes to paclitaxel resistance in ovarian cancer cells and that CTSL silencing can enhance paclitaxel mediated cell apoptosis (Figure 5A and 5B). The gene discussed is CTSL; the disease is ovarian carcinoma.