As both p21WAF1/CIP1 and BIM are validated targets in prostate cancer and human mammary epithelial cells [18, 19], we studied p21WAF1/CIP1 and BIM protein expression in two MLL-rearranged cell lines, Nomo1 and THP-1, after overexpression of the miR-106b~25 cluster. The gene discussed is CDKN1A; the disease is prostate cancer.