To further confirm that p53 signaling was involved in the regulation of USP2, we investigated whether USP2 was inducedby nutlin3a or PUVA in the other CTCL cell lines with functional p53 signaling (Mac2a) and impaired p53 signaling, SeAx (p53mut) and Hut-78 (p53−/−) [29]. Here, TP53 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.