Further underscoring complexity at the locus, in one of these studies no association with schizophrenia was observed when the CYFIP1 regulatory variant rs4778334 was considered in isolation, but a clear signal was seen when the effect of a second eQTL variant at the ACTR2 gene encoding an interacting protein was taken into account [28]. The gene discussed is CYFIP1; the disease is schizophrenia.