Numerous mutations in NKX2.5 have been reported with various CHD phenotypes, such as secundum atrial septal defect, tetralogy of Fallot, truncus arteriosus, double-outlet right ventricle, L-transposition of great arteries, interrupted aortic arch, ventricular noncompaction, and hypoplastic left heart, with or without conduction disorders [62, 78]. This evidence concerns the gene NKX2-5 and coronary artery disorder.