RET and colorectal carcinoma: In particular, real-time RT-PCR analyses showed a nearly complete abrogation of RET mRNA levels in cells exposed for 48 h to 1 μM (0.24 ± 0.03 and 0.20 ± 0.01 relative quantity with respect to untreated cells in MZ CRC-1 and TT cells, respectively) and 2 μM (0.14 ± 0.02 and 0.08 ± 0.006 relative quantity with respect to untreated cells in MZ CRC-1 and TT cells, respectively) of the compound (Figure 1C).