One of the most popular models for detection of insignificant prostate cancer was described in widely acknowledged works of Epstein et al. [2] and Bastian et al. [3], who identified the following criteria based on the preoperative biopsy findings: no Gleason pattern 4 or 5, two or less cores with cancer, and less than 50% of any core involved with prostate specific antigen (PSA) density less than 0.15. The gene discussed is KLK3; the disease is Familial prostate cancer.