KLK3 and cancer: For radical prostatectomy, tumor volume >0.5 mL was applied, as well as Gleason grade > 4 and nonlocalized cancer (stage > T3a/N1), whereas, for men who chose radiotherapy or active surveillance, tumor volume had no significance and the definition incorporating Gleason > 4, PSA > 10 ng/mL, or PSA density > 0.15 was used [74].