Despite the fact that an early study in a group of Italian patients failed to identify LOX mutations [28], further extensive genotyping in multiple samples of independently collected KC patients around the world confirmed the effect of SNP rs2956540 in LOX in Czech KC cases of European descent [29], Chinese cases [30], Iranian cases [31], and in a recent meta-analysis of published studies [32]. The gene discussed is LOX; the disease is keratoconus.