SNPs associated with the following genes have been implicated: LOX, CAST, DOCK9, IL1RN, SLC4A11, HGF, RAB3GAP1, TGFBI, ZNF469, ZEB1, VSX1, COL5A1, COL4A3, COL4A4, FNDC3B, FOXO1, MPDZ-NF1B, WNT10A, SOD1, IL1B, IL1A, in addition to the microRNA MIR184. Notably, not all analyses of each of these genes completely confirm their role in KC pathogenesis. The gene discussed is CAST; the disease is keratoconus.