In particular, a unique coding mutation c.1920G > T (p.Gln640His) in this gene has been first identified in a family with KC and FECD [84] and later in a patient with triple corneal dystrophy consisting of KC, epithelial basement membrane corneal dystrophy (EBMCD) and FECD [85] thus, further supporting mutational spectrum of ZEB1 with a unique genotype/phenotype correlation. The gene discussed is ZEB1; the disease is keratoconus.