IL6 and colorectal carcinoma: In terms of CRC risk, the effect of alcohol drinking was evident only in the subgroup of IL-6 C-allele carriers (OR = 2.19, 95 % CI, 1.3–3.7), and the use of NSAIDs halved the risk from 2.02 (95 % CI, 1.38–2.95) to 1.02 (95 % CI, 0.65–1.61) in the carriers of the C-allele.