Squamous cell carcinomas were found in 2 HRN gpt delta-AAI mice (2/8), which had penetrated through the stomach to invade the esophagus, glandular stomach, and other surrounding tissues (Fig. 4c), and 1 metastasis was present in the liver had invaded the esophagus (Fig. 4e). This evidence concerns the gene GPT and squamous cell carcinoma.