Here, we have found both TLR4 Asp299Gly and Thr399Ile polymorphisms to cause a 3.8 -5.3-fold increased risk of severe anaemia and 3.5 – 4.4-fold increased risk of high parasite density, while Thr399Ile polymorphism alone raised the risk of fever 5-fold. Here, TLR4 is linked to anemia (phenotype).