Malaria is an inflammatory disease, which is initiated through recognition of parasite toxin such as glycophosphatidyl inositol (GPI) by innate immune cells such as monocytes, dendritic and macrophages for activation and elicitation of intracellular signal transduction pathway for the production of pro-inflammatory cytokines such tumor necrosis factor-alpha (TNF-α), interleukin-12 (IL-12) and interferon gamma (IFN-γ) [4, 5]. The gene discussed is TNF; the disease is malaria.