However, unlike in the Burundian children, we found MAF of 17.6 % and 10.4 % for TLR4 Asp299Gly and Thr399Ile among our severe malaria sub-group with genotypes containing these alleles further found to increase the risk of severe malaria 3-fold and 8-fold respectively. The gene discussed is TLR4; the disease is malaria.