For example, mutations in FGFR1, BRAF, RET, MET, HER-2 occur in about 3% of all NSCLC [21], and since tumours bearing these mutations were already successfully treated with targeted therapies in other types cancers, it has been hypothesised that they might be effective in NSCLC as well. The gene discussed is RET; the disease is non-small cell lung carcinoma.