Recently, failure of GluA2 Q/R site-editing has been demonstrated in the motor neurons of an ALS patient with FUSP525L mutation14, 32 and in the pathological tissues of ALS patients carrying the C9ORF72 gene with hexanucleotide repeat expansion33, suggesting that efficacy of perampanel would be expected in some form of familial ALS patients, as well. The gene discussed is GRIA2; the disease is amyotrophic lateral sclerosis.