Downregulation using siRNA or blocking of the channel lead to growth inhibition of cancer cells in vitro and in vivo (Garcia-Ferreiro et al. 2004; Gomez-Varela et al. 2007; Weber et al. 2006); siRNA knockdown of Kv10.1 shows synergistic effects with TRAIL overexpression in osteosarcoma models (Wu et al. 2013). This evidence concerns the gene TNFSF10 and cancer.