PYCARD and cancer: 47 indicated that Src was associated with caspase‐8 through death domain (DED) and enhanced Erk signaling. Barbero et al. 32 reported that phosphorylation of Tyr380 in caspase‐8 was critical for the promotion of cancer cell migration, and explained that caspase‐8 associated with focal adhesion complex, including FAK and Calpain 2, and it promoted tumor cell migration and metastasis 48. Furthermore, it has been reported that ASC bound to caspase‐8 DED through its PYD 33, 34.