PYCARD and renal cell carcinoma: 16 demonstrated that ASC was epigenetically inactivated in 41.1% of renal cell carcinoma (RCC) and suggested a role of tumor suppressor. Wu et al. 17 reported that hypermethylation of the ASC/TMS1 promoter was significantly associated with greater lymph node metastasis, associated with a poor prognosis in patients with gastric cancer, and should be considered as a key prognostic indicator.