In addition to the highly penetrant (BRCA1, BRCA2, and TP53) and moderately penetrant (CHEK2, BRIP1, ATM and PALB2) genetic variants, breast cancer has been associated with low penetrant risk (FGFR2, TNRC9, MAP3K1 and LSP1)11. This evidence concerns the gene TOX3 and breast cancer.