Therefore, we investigated whether decreased ER stress in response to IL-22 treatment was accompanied by decreased oxidative stress and inflammation and found obesity-induced intestinal Nos2, Il1b, Tnfa and Il17a mRNA expression was markedly reduced by IL-22, with evidence for a dose dependent effect (Fig. 6d–g). Here, NOS2 is linked to obesity due to melanocortin 4 receptor deficiency.