SOX2 and glioblastoma: GSC share many properties with normal neural stem cells (NSC), such as stem cell markers expression (Sox2, Nestin, CD133, ALDH1, etc.)and multilineage differentiation and, importantly, extensive evidence indicates that NSC themselves can be cells of origin in GBM (Chen et al., 2012b; Venere et al., 2011; Chen et al., 2012a).