GSC share many properties with normal neural stem cells (NSC), such as stem cell markers expression (Sox2, Nestin, CD133, ALDH1, etc.)and multilineage differentiation and, importantly, extensive evidence indicates that NSC themselves can be cells of origin in GBM (Chen et al., 2012b; Venere et al., 2011; Chen et al., 2012a). This evidence concerns the gene NES and glioblastoma.