Indeed, EphA2 and EphA3 were shown to drive GSC self-renewal, whereas EphA2, EphA4, EphB2, ephrin-B2 and ephrin-B3 have all been linked to GBM invasion, through incompletely understood mechanisms (Day et al., 2014; Tu et al., 2012; Binda et al., 2012; Day et al., 2013; Nakada et al., 2010; 2011). Here, EFNB2 is linked to glioblastoma.