We also profiled innate immune cell populations involved in the sterile inflammatory response in our NASH mouse model, and observed only significant CXCL10-dependent reduction of hepatic proinflammatory (M1 polarized) macrophages accumulation and activation, when compared to other innate immune cells involved in the hepatic inflammation in NASH. This evidence concerns the gene CXCL10 and metabolic dysfunction-associated steatohepatitis.