Although the MCD diet replicates the histological features of steatohepatitis and fibrosis observed in human NASH, its metabolic context is distinct from human NASH, since animal fed the MCD diet lose up to 40% of their weight in 10 weeks, have low fasting blood sugar, peripheral insulin sensitivity, low serum insulin, decreased blood triglyceride and cholesterol36, 37. The gene discussed is INS; the disease is metabolic dysfunction-associated steatohepatitis.