TLR4 and Sepsis: For example, José C and colleagues36 demonstrated that TLR4 signaling is not essential in sub-lethal polymicrobial sepsis induced by both CLP and polymicrobial inoculation models, but it is crucial in lethal polymicrobial sepsis, since TLR4-deficient mice that underwent lethal CLP or polymicrobial inoculation presented low bacteremia and a high survival rate and did not display systemic inflammation.