In the current study, we noted that: a) intrapulmonary αvβ3 is increased by polymicrobrial sepsis in a TLR4, CD14 dependent fashion; b) β3 is required for WISP1 to enhance TLR4 mediated activation of TNF-α release from primary cultures of PMø; and c) ERK signaling is important in enhancing and transducing WISP1 synergetic effect. This evidence concerns the gene TLR4 and Sepsis.