Our recent studies using novel fiber-chimeric Ad.5/3-CTV CRAd demonstrated improved CAR-independent infection efficiency in low CAR human prostate cancer cells as compared to Ad.5-CTV in vitro while resulting in potent suppression of tumor xenograft growth in a nude mouse model [46, 47] and in a spontaneously induced prostate cancer in Hi-myc transgenic mice [48]. This evidence concerns the gene MYC and prostate carcinoma.