It was previously shown that Ad5-based CRAd vector engineered to contain the E1A gene under transcriptional control of the promoter region of rodent progression elevated gene-3 and simultaneously express IL-24 gene in place of the deleted E3 region, referred to as cancer terminator virus (CTV), eradicates both primary and distant human breast carcinoma, melanoma, and therapy-resistant prostate cancer cells xenotransplanted in athymic nude mice [41–45]. This evidence concerns the gene IL24 and cancer.