AKT1 and Familial prostate cancer: The PI3K/Akt pathway is one of the most commonly altered pathways in epithelial cancers including prostate cancers.24 Of importance is the reciprocal feedback regulation in prostate cancer cells between androgen receptor signaling and signaling through the PI3K/Akt/mTOR pathway, which has been implicated in the emergence of androgen-independent tumors.