INS and Hyperglycemia: ADT is associated with increased IR, independent of body composition and age.46 Compromised insulin sensitivity as a result of ADT occurs as an early consequence, increases in severity over time, and eventually culminates in hyperglycemia and finally type 2 diabetes.37 ADT further exacerbates insulin metabolism by increasing fasting insulin levels44, 47 and decreasing insulin sensitivity.48, 49 Changes in insulin sensitivity have been noted with short (12 weeks)49 or long-term (over 45 months)46 ADT use.