F2,6BP effectively reversed the EGCG-induced enhancement of the pro-apoptotic effect of Bax and Bak and the decreased anti-apoptotic effect of Bcl-2 and Bcl-xl in HCC-LM3 and HepG2 cells (Fig. 7), suggesting that other Bcl-2 family proteins are involved in EGCG-induced apoptosis. This evidence concerns the gene BAX and hepatocellular carcinoma.