In addition, F2,6BP, an activator of PFK, significantly attenuated EGCG-induced apoptosis, especially mitochondrial apoptosis, in aerobic glycolytic HCC cells, as indicated by the inhibition of the loss of Δψm, the increase of activated caspases, and the release of cytochrome c (Fig. 5). Here, CYCS is linked to hepatocellular carcinoma.