Different mechanisms have been proposed to explain the cancer-preventive effect of EGCG24, 25 in addition to its widely known antioxidant potential26, the upregulation of tumor suppressor genes such as p5327, and the modulation of cell signaling pathways, such as the inhibition of nuclear factor-κB (NF-κB)28, mitogen-activated protein kinase (MAPK)29, epidermal growth factor receptor (EGFR)18, and insulin-like growth factor (IGF)30. The gene discussed is EGFR; the disease is cancer.