Detailed investigation of gene expression profiles in the GEO database (RRID:SCR_004584) provides evidence of differential TRIP6 expression during rodent development of the mammary gland (GDS2721 and GDS2360)25, 26, gonads (GDS4503)27, and hypothalamus (GDS2862) as well as in the hypothalamic hamartomas of patients with central precocious puberty (GDS3110)28. This evidence concerns the gene TRIP6 and congenital hypothalamic hamartoma syndrome.