RPA1 and infection: In EBV, the viral replication machinery consisting of the BALF5 DNA polymerase, BMRF1 DNA polymerase processivity factor, BALF2 single-stranded DNA binding protein, and the BBLF4-BSLF1-BBLF2/3 helicase-primase complex replicate the EBV genome during productive infection in discrete nuclear sites called factories.