Characteristics of LC patients according to PI-including regimen are described on Table 1: 326 (23.9%) patients were women, 25% were non-Italian, median CD4 count was 165 cells/mmc (IQR: 59–266), median HIV RNA log 10 copy levels/ml was 5.00 (4.40–5.49), 150 (11.0%) had a diagnosis of AIDS at baseline. The gene discussed is CD4; the disease is laryngotracheoesophageal cleft.