But first of all, also in these categories of severely immunodepressed patients, and roughly 50% with a viral load >5 log10 HIV-RNA copies/ml, the likehood of virological failure was low, accounting for 2.8% and 4.3% by the first year in those presenting with CD4 counts less than 350 and less than 200/mm3 or AIDS respectively. Here, CD4 is linked to AIDS.