The ability of dietary fibre to suppress AOM/DSS-induced weight loss, diarrhea and development of colonic polyps was dependent on Ffar2, because Ffar2−/− mice fed with either FF or FP diets exhibited weight loss, diarrhea and colonic polyps, which were comparable with outcomes observed in WT littermates fed with FF diet (Figures 5a–d). The gene discussed is FFAR2; the disease is infectious otitis media.