The ability of dietary fibre to suppress AOM/DSS-induced weight loss, diarrhea and development of colonic polyps was dependent on Ffar2, because Ffar2−/− mice fed with either FF or FP diets exhibited weight loss, diarrhea and colonic polyps, which were comparable with outcomes observed in WT littermates fed with FF diet (Figures 5a–d). Here, FFAR2 is linked to intestinal disorder.