RASSF10 and hepatocellular carcinoma: Some other signal pathways modulating MMP2 by RASSF10 could be involved in HCC cells, such as FAK or MAPK signaling pathway.26, 27, 38 FAK is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes.39 FAK activity elicits intracellular signal transduction pathways that promote the cells contacting with the extracellular matrix and promoting cell migration.