Some other signal pathways modulating MMP2 by RASSF10 could be involved in HCC cells, such as FAK or MAPK signaling pathway.26, 27, 38 FAK is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes.39 FAK activity elicits intracellular signal transduction pathways that promote the cells contacting with the extracellular matrix and promoting cell migration. Here, PTK2 is linked to hepatocellular carcinoma.