RASSF10 and hepatocellular carcinoma: Concordance with the latest report about RASSF10 in gastric carcinoma, we also observed mild methylation of RASSF10 in normal liver, but the expression of RASSF10 was not decreased.29 The normal tissue exhibited much weaker extent of methylation than those HCC cells, which showed down-regulated or silenced RASSF10 (Supplementary Figure 1a), indicating the inactivity of transcription induced by methylation could be associated with the extent of promoter methylation.