PKC activators, including phorbol esters, inhibited growth of various non-uveal melanoma cell lines and tumors through inducement of cell-cycle arrest or apoptosis.53, 54, 55, 56 Wild-type PKC rescue of loss-of-function PKC alleles in human tumor cells inhibited tumorigenesis, showing that PKC is a tumor suppressor.57 Our demonstration in Figure 6b that host animal systemic TPA treatment delayed melanoma tumor onset and progression from a grafted GNAQQ209L cell line is highly encouraging. This evidence concerns the gene PRRT2 and neoplasm.