RIC8A and infection: Ric-8A deletion in the melanocyte cell line mediated by Cre-NLS lentiviral infection or by 4-hydroxytamoxifen (4OHT) activation of Cre recombinase, decreased Ric-8A abundance and caused concomitant decreases in the levels of G protein subunits folded by Ric-8A (Figure 1b).