Gαq/11 oncoprotein cancer signaling is thought to be primarily driven by the distinct Rho/YAP branch of the Gq/11 signaling axis.17, 45 When oncoprotein levels are reduced by feedback inhibition through PKC, cancer signaling through Rho/YAP would also be reduced, potentially explaining the great difference in frequency of cutaneous versus uveal melanomas driven by oncogenic GNAQ/11. This evidence concerns the gene PRRT2 and uveal melanoma.