Our results indicated no significant difference in concentration of HMGB1 among different age groups (for HFRS patients p = 0.95 and for CCHF patients p = 0.82) or genders (for HFRS patients p = 0.84 and for CCHF patients p = 0.34) in patients with hemorrhagic fevers (supplement data, S2 and S3 Figs). Here, HMGB1 is linked to hemorrhagic fever.